期刊
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
卷 126, 期 5, 页码 377-388出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13813455.2018.1543329
关键词
Diabetes mellitus; metformin; oxidative stress; inflammation; apoptosis
资金
- yy
Context: Metformin's effect on glycaemic control is well documented, but its effect on diabetes-induced testicular impairment has been scarcely reported. Objective: To investigate the effects of metformin on testicular oxidative stress, inflammation, and apoptosis, which largely contribute to fertility decline in diabetic state. Methods: Male Sprague-Dawley rats were divided into 3 groups (n = 6/group) namely: normal control (NC), diabetic control (DC), and metformin (300 mg/kg b.w./d)-treated diabetic groups. Metformin was administrated for 4 weeks. Results: Decreased mRNA expressions and activities of antioxidant enzymes were seen in the testes of DC group. mRNA and protein expressions of pro-inflammatory and pro-apoptotic markers increased, while interleukin-10 and proliferating cell nuclear antigen (PCNA) decreased in the testes of DC group. Treatment with metformin up-regulated antioxidant enzymes, down-regulated inflammation, and apoptosis and increased PCNA immunoexpression in the testes. Conclusions: Metformin protects the testes from diabetes-induced impairment and may improve male reproductive health in diabetic state.
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