期刊
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
卷 1854, 期 9, 页码 1132-1137出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2014.12.015
关键词
Calcium signaling; Cyclic ADP-ribose; ADP-ribose; NAADP; NAD; Cofactor
资金
- Deutsche Forschungsgemeinschaft [GU 360/15-1, 18-1]
- Gemeinnutzige Hertie-Stiftung [P1140086]
- Research Initiative of the City of Hamburg (Research network ReAd Me: Regulatory Adenine nucleotides on Membranes)
- Welcome Trust
- Deutsche Forschungsgemeinschaft
Nicotinamide adenine dinucleotide (NAD) has been known since along period of time as co-factor of oxidoreductases. However, in the past couple of decades further roles have been assigned to NAD. Here, metabolism of NAD to the Ca2+ mobilizing second messengers cyclic adenosine diphosphoribose, nicotinic acid adenine dinudeotide phosphate and adenosine diphosphoribose is reviewed. Moreover, the mechanisms of Ca2+ mobilization by these adenine nucleotides and their putative target Ca2+ channels, ryanodine receptors and transient receptor potential channels are discussed. This article is part of a Special Issue entitled: Cofactor-dependent proteins: evolution, chemical diversity and bio-applications. (C) 2014 Elsevier B.V. All rights reserved.
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