期刊
ENTOMOLOGICAL RESEARCH
卷 49, 期 1, 页码 26-34出版社
WILEY
DOI: 10.1111/1748-5967.12323
关键词
Apis mellifera; Ascosphaera apis; chalkbrood; immune response; Transcriptome
类别
资金
- Key science and technology program of Jilin Province [20150204065NY]
- Special Fund for Agro-scientific Research in the Public Interest of China [201303091]
- Construction Program of Modern Agricultural Industry Technology System of China [CARS-38]
Chalkbrood, which results from Ascosphaera apis infection, is one of the bee diseases that causes serious damage to the bee colony. Understanding the molecular bases underlying immune response to chalkbrood disease would facilitate the genetic breeding of bees by selecting races with superior chalkbrood resistance. In this study, transcriptome sequencing was performed to identify genes and pathways involved in the immune response to As. apis infection in A. mellifera larvae. In total, 2,890 differentially expressed genes (DEGs) (FDR < 0.001) were identified between the healthy and As. apis infected bee larvae, including 2,214 up-regulated and 676 down-regulated unigenes. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway classification of the DEGs revealed association with development, energy metabolism, signal transduction, disease, and immune response. Among the immune-related genes, p38, toll-like receptors (TLRs), integrin, and antimicrobial peptides were up-regulated under As. apis infection. This study provides valuable gene transcriptional information towards the investigation of molecular mechanisms related to chalkbrood immune response and host pathogenesis in A. mellifera.
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