期刊
ANNUAL REVIEW OF ANIMAL BIOSCIENCES, VOL 7
卷 7, 期 -, 页码 245-+出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-animal-020518-115300
关键词
exosomes; extracellular vesicles; microRNA; milk; RNA
类别
资金
- NIGMS NIH HHS [P20 GM104320] Funding Source: Medline
Exosomes are natural nanoparticles that play an important role in cell-to-cell communication. Communication is achieved through the transfer of cargos, such as microRNAs, from donor to recipient cells and binding of exosomes to cell surface receptors. Exosomes and their cargos are also obtained from dietary sources, such as milk. Exosome and cell glycoproteins are crucial for intestinal uptake. A large fraction of milk exosomes accumulates in the brain, whereas the tissue distribution of microRNA cargos varies among distinct species of microRNA. The fraction of milk exosomes that escapes absorption elicits changes in microbial communities in the gut. Dietary depletion of exosomes and their cargos causes a loss of circulating microRNAs and elicits phenotypes such as loss of cognitive performance, increase in purine metabolites, loss of fecundity, and changes in the immune response. Milk exosomes meet the definition of bioactive food compounds.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据