期刊
POLYMERS
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/polym10101098
关键词
nanogel; photothermo-responsive; N-isopropylacrylamide; sodium copper chlorophyllin; drug delivery; anti-cancer
资金
- Advanced Research Center for Green Materials Science and Technology from The Featured Area Research Center Program within the Ministry of Education [107L9006]
- Ministry of Science and Technology in Taiwan [MOST 107-3017-F-002-001, 105-2923-E-002-017-MY2]
Temperature stimulus, easy modulation in comparison to other environmental stimuli, makes thermo-responsive nanocarriers popular in the applications of controlled drug release for cancer therapy. In this study, photosensitive sodium copper chlorophyllin (SCC) was incorporated into thermo-responsive polymeric nanogels consisted of N-isopropylacrylamide and N-(hydroxymethyl)acrylamide. Significant heat was generated from the SCC-containing nanogels under the exposure to 532-nm green laser, and resulted in cell mortality. The thermo-responsive nanogel loaded with 5-FU, an anti-cancer drug, released the drug explosively when exposed to green laser. The combination of hyperthermia and temperature-induced drug release via green laser irradiation greatly enhanced cell mortality to a maximal extent. Such photothermo-responsive nanogel possesses a great potential in anti-cancer treatment.
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