期刊
PLOS GENETICS
卷 14, 期 11, 页码 -出版社
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pgen.1007757
关键词
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资金
- UK Medical Research Council [MR/M021475/1]
- US National Institutes of Health [AG046938]
- European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/grant [602768]
- ERC [295366]
- Medical Research Council Professorship award [G19/2]
- MRC/IoPPN Excellence Award
- Sir Henry Dale Fellowship - Wellcome Trust [107706/Z/15/Z]
- Sir Henry Dale Fellowship - Royal Society [107706/Z/15/Z]
- National Institute for Health Research (NIHR) Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King's College London
- GSTT Charity [TR130505]
- Maudsley Charity [980]
- MRC [G19/2, MR/M021475/1, MR/N015746/1] Funding Source: UKRI
- NATIONAL INSTITUTE ON AGING [R01AG046938] Funding Source: NIH RePORTER
The parental feeding practices (PFPs) of excessive restriction of food intake ('restriction') and pressure to increase food consumption ('pressure') have been argued to causally influence child weight in opposite directions (high restriction causing overweight; high pressure causing underweight). However child weight could also 'elicit' PFPs. A novel approach is to investigate gene-environment correlation between child genetic influences on BMI and PFPs. Genome-wide polygenic scores (GPS) combining BMI-associated variants were created for 10,346 children (including 3,320 DZ twin pairs) from the Twins Early Development Study using results from an independent genome-wide association study meta-analysis. Parental 'restriction' and 'pressure' were assessed using the Child Feeding Questionnaire. Child BMI standard deviation scores (BMI-SDS) were calculated from children's height and weight at age 10. Linear regression and fixed family effect models were used to test between- (n = 4,445 individuals) and within-family (n = 2,164 DZ pairs) associations between the GPS and PFPs. In addition, we performed multivariate twin analyses (n = 4,375 twin pairs) to estimate the heritabilities of PFPs and the genetic correlations between BMI-SDS and PFPs. The GPS was correlated with BMI-SDS = 0.20, p= 2.41x10(-38)). Consistent with the gene-environment correlation hypothesis, child BMI GPS was positively associated with 'restriction' (beta = 0.05, p = 4.19x10(-4)), and negatively associated with 'pressure' (beta = -0.08, p = 2.70x10(-7)). These results remained consistent after controlling for parental BMI, and after controlling for overall family contributions (within-family analyses). Heritabilities for 'restriction' (43% [40-47%]) and 'pressure' (54% [50-59%]) were moderate-to-high. Twin-based genetic correlations were moderate and positive between BMI-SDS and 'restriction' (r(A) = 0.28 [0.23-0.32]), and substantial and negative between BMI-SDS and 'pressure' (r(A) = -0.48 [-0.52 - -0.44]. Results suggest that the degree to which parents limit or encourage children's food intake is partly influenced by children's genetic predispositions to higher or lower BMI. These findings point to an evocative gene-environment correlation in which heritable characteristics in the child elicit parental feeding behaviour.
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