4.3 Article

Twist and E-cadherin deregulation might predict poor prognosis in lower lip squamous cell carcinoma

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ELSEVIER SCIENCE INC
DOI: 10.1016/j.oooo.2018.11.003

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  1. Postgraduate Program in Oral Pathology of the Federal University of Rio Grande do Norte
  2. Coordination for the Improvement of Higher Education Personnel CAPES

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Objective. The aim of this study was to evaluate the expression of Twist and E-cadherin in lower lip squamous cell carcinoma (LLSCC) and their association with clinicopathologic parameters. Study Design. Fifty-nine cases of LLSCC were analyzed by applying immunohistochemistry techniques in a semiquantitative manner. The systems proposed by Bryne et al., Brandwein-Gensler et al., and Almangush et al. were applied for analysis of the histopathologic malignancy grading system. Results. Higher E-cadherin expression (general and membrane) was observed in cases presenting with disease-free survival after 5 years of follow-up (P < .05). Higher Twist expression was observed in lesions classified as being in advanced stages, displaying recurrence, and having a high degree of malignancy. A significant negative correlation was detected between cytoplasmic Twist expression and membrane E-cadherin expression (P = .028). A statistically significant relationship was detected between high total Twist expression in tumors classified as high risk by Brandwein-Gensler et al., and no significant difference was observed among total, membrane, and cytoplasmic E-cadherin expressions in LLSCC cases and the 3 applied grading systems (P > .05). Conclusions. The results of the present study suggest the potential involvement of Twist and E-cadherin in the modulation of events related to worse prognoses in LLSCC cases.

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