The trigger (and the restriction) of Torso RTK activation

The Torso pathway is an ideal model of receptor tyrosine kinase systems, in particular when addressing questions such as how receptor activity is turned on and, equally important, how it is restricted, how different outcomes can be generated from a single signal, and the extent to which gene regulation by signalling pathways relies on the relief of transcriptional repression. In this regard, we considered it pertinent to single out the fundamental notions learned from the Torso pathway beyond the specificities of this system (Furriols and Casanova 2003 EMBO J. 22, 1947-1952. (doi: 10.1093/emboj/cdg224)). Since then, the Torso system has gained relevance and its implications beyond its original involvement in morphogenesis and into many disciplines such as oncogenesis, hormone control and neurobiology are now acknowledged. Thus, we believe that it is timely to highlight additional notions supported by new findings and to draw attention to future prospects. Given the late development of research in the field, we wish to devote this review to the events leading to the activation of the Torso receptor, the main focus of our most recent work.