期刊
ACTA PHARMACOLOGICA SINICA
卷 37, 期 6, 页码 719-730出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/aps.2015.155
关键词
Alzheimer's disease; diagnostic biomarker; amyloid-beta; optical imaging; near-infrared fluorescent probes
资金
- National Natural Science Foundation of China [81522045, 81225022]
With accumulating evidence suggesting that amyloid-beta (A beta) deposition is a good diagnostic biomarker for Alzheimer's disease (AD), the discovery of active A beta probes has become an active area of research. Among the existing imaging methods, optical imaging targeting A beta aggregates (fibrils or oligomers), especially using near-infrared (NIR) fluorescent probes, is increasingly recognized as a promising approach for the early diagnosis of AD due to its real time detection, low cost, lack of radioactive exposure and high-resolution. In the past decade, a variety of fluorescent probes have been developed and tested for efficiency in vitro, and several probes have shown efficacy in AD transgenic mice. This review classifies these representative probes based on their chemical structures and functional modes (dominant solvent-dependent mode and a novel solvent-independent mode). Moreover, the pharmaceutical characteristics of these representative probes are summarized and discussed. This review provides important perspectives for the future development of novel NIR A beta diagnostic probes.
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