期刊
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
卷 12, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnbeh.2018.00334
关键词
fruit fly; mate choice; social learning; social memory; 3-iodotyrosine (3-IY); DL-parachlorophenylalanine (PCPA); L-3,4-dihydroxyphenylalanine (L-DOPA); 5-L-hydroxytryptophan (5-HTP)
资金
- Laboratoires d'Excellence (LABEX) TULIP [ANR-10-LABX-41]
- Toulouse Initiative of Excellence IDEX UNITI [ANR11-IDEX-0002-02]
- MoleCulture project from Agence Nationale pour la Recherche [ANR-18-CE37-0015]
- Soc-H2 ANR project [ANR-13-BSV7-0007-01]
- French ministry of higher education and research
- Soc-H2, a Marie Curie PRESTIGE grant [PRESTIGE-2014-1-0005]
- ANR-Labex Institute for Advanced Study in Toulouse
- Agence Nationale de la Recherche (ANR) [ANR-18-CE37-0015] Funding Source: Agence Nationale de la Recherche (ANR)
Mate-copying is a form of social learning in which the mate-choice decision of an individual (often a female) is influenced by the mate-choice of conspecifics. Drosophila melanogaster females are known to perform such social learning, and in particular, to mate-copy after a single observation of one conspecific female mating with a male of one phenotype, while the other male phenotype is rejected. Here, we show that this form of social learning is dependent on serotonin and dopamine. Using a pharmacological approach, we reduced dopamine or serotonin synthesis in adult virgin females with 3-iodotyrosine (3-IY) and DL-para-chlorophenylalanine (PCPA), respectively, and then tested their mate-copying performance. We found that, while control females without drug treatment copied the choice of the demonstrator, drug-treated females with reduced dopamine or serotonin chose randomly. To ensure the specificity of the drugs, the direct precursors of the neurotransmitters, either the dopamine precursor L-3,4 - dihydroxyphenylalanine (L-DOPA) or the serotonin precursor 5-L-hydroxytryptophan (5-HTP) were given together with the drug, (respectively 3-IY and PCPA) resulting in a full rescue of the mate-copying defects. This indicates that dopamine and serotonin are both required for mate-copying. These results give a first insight into the mechanistic pathway underlying this form of social learning in D. melanogaster.
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