期刊
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
卷 26, 期 5, 页码 458-470出版社
OXFORD UNIV PRESS
DOI: 10.1177/2047487318822354
关键词
African-PREDICT; hypertension; ethnicity; race; black; biomarkers; cohort; longitudinal; young; organ damage
资金
- South African Medical Research Council (SAMRC)
- national treasury under its economic competitiveness and support package
- South African Research Chairs Initiative (SARChI) of the Department of Science and Technology [GUN 86895]
- National Research Foundation (NRF) of South Africa [GUN 86895]
- SAMRC
- South African National Department of Health, GlaxoSmithKline R&D (Africa non-communicable disease open lab grant)
- UK Medical Research Council
- UK Government's Newton Fund
- Pfizer (South Africa)
- Boehringer-Ingelheim (South Africa)
- Novartis (South Africa)
- MediClinic Hospital Group (South Africa)
- MRC [MC_PC_16095] Funding Source: UKRI
Background Globally hypertension is stabilising, but in sub-Saharan Africa the incidence of hypertension remains on an increase. Although this might be attributed to poor healthcare and ineffective antihypertensive treatment, there is a limited understanding of population and individual-specific cardiovascular pathophysiology - necessary for effective prevention and treatment strategies in Africa. As there is a lack of longitudinal studies tracking the early pathophysiological development of hypertension in black populations, the African-PREDICT study was initiated. The purpose of this paper is to describe the detailed methodology and baseline cohort profile of the study. Methods and results From 2013 to 2017, the study included 1202 black (N = 606) and white (N = 596) men and women (aged 20-30 years) from South Africa - screened to be healthy and clinic normotensive. At baseline, and each 5-year follow-up examination, detailed measures of health behaviours, cardiovascular profile and organ damage are taken. Also, comprehensive biological sampling for the 'omics' and biomarkers is performed. Overall, the baseline black and white cohort presented with similar ages, clinic and 24-hour blood pressures, but black adults had lower socioeconomic status and higher central systolic blood pressure than white individuals. Conclusions The prospective African-PREDICT study in young black and white adults will contribute to a clear understanding of early cardiovascular disease development.
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