期刊
CELL REPORTS
卷 25, 期 7, 页码 1912-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2018.10.044
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资金
- Australian National Health and Medical Research Council [GNT1098290, GNT1105754]
- Australian Research Training Program Fellowship
- Bellberry-Viertel Senior Medical Research Fellowship
We and others have recently reported that the SMC protein Smchd1 is a regulator of chromosome conformation. Smchd1 is critical for the structure of the inactive X chromosome and at autosomal targets such as the Hox genes. However, it is unknown how Smchd1 is recruited to these sites. Here, we report that Smchd1 localizes to the inactive X via the XistHnrnpK-PRC1 (polycomb repressive complex 1) pathway. Contrary to previous reports, Smchd1 does not bind Xist or other RNA molecules with any specificity. Rather, the localization of Smchd1 to the inactive X is H2AK119ub dependent. Following perturbation of this interaction, Smchd1 is destabilized, which has consequences for gene silencing genome-wide. Our work adds Smchd1 to the PRC1 silencing pathway for X chromosome inactivation.
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