期刊
CELL REPORTS
卷 25, 期 3, 页码 585-+出版社
CELL PRESS
DOI: 10.1016/j.celrep.2018.09.059
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资金
- Swedish Cancer Society
- Swedish Foundation for Strategic Research
- Ragnar Soderberg Foundation
- Stiftelsen Gosta Miltons Donationsfond
- Karolinska Institutet KID fund
- Knut and Alice Wallenberg Foundation
- Swedish Research Council
- Center for Innovative Medicine
- Jonasson donation to the School of Technology and Health
- Royal Institute of Technology, Sweden
Epithelial tissues, such as the skin, rely on cellular plasticity of stem cells (SCs) from different niches to restore tissue function after injury. How these molecularly and functionally diverse SC populations respond to injury remains elusive. Here, we genetically labeled Lgr5- or Lgr6-expressing cells from the hair follicle bulge and interfollicular epidermis (IFE), respectively, and monitored their individual transcriptional adaptations during wound healing using single-cell transcriptomics. Both Lgr5 and Lgr6 progeny rapidly induced a genetic wound signature that, for Lgr5 progeny, included the remodeling of receptors to permit interactions with the wound environment, a property that Lgr6 progeny possessed even before wounding. When contributing to reepithelialization, Lgr5 progeny gradually replaced their bulge identity with an IFE identity, and this process started already before Lgr5 progeny left the bulge. Altogether, this study reveals how different SCs respond and adapt to a new environment, potentially explaining cellular plasticity of many epithelial tissues.
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