期刊
ADVANCED HEALTHCARE MATERIALS
卷 7, 期 23, 页码 -出版社
WILEY
DOI: 10.1002/adhm.201800973
关键词
bioimaging; PEGylation; second near-infrared window; self-assembly; small-molecule dyes
资金
- National Key RD Program [2017YFA0505203]
- NSFC [21708012, 21772055]
- NSFHP [2017CFB151]
- CCNU from the colleges, basic research and operation of MOE [23020205170469]
- 111 project [B17019]
- Open Research Fund of State Key Laboratory of Analytical Chemistry for Life Science [SKLACLS1815]
To date, small-molecule dye-based probes have been at the forefront of research in biomedical imaging, especially in the second near-infrared (NIR-II) window (1.0-1.7 mu m). However, how to precisely regulate the synthesized size of NIR-II organic dye-based probes remains challenging. Moreover, systematic studies on whether the size of NIR-II probes affects optical/pharmacokinetic properties are still rare. Here, an ingenious PEGylation strategy is developed to regulate the self-assembly size of organic dye-based (CH1055 scaffold) NIR-II probes (SCH1-SCH4) from nanoparticles to the single molecule, and the relationship between their size and chemical/physical properties is thoroughly investigated. Based on their own merits, nanoprobe SCH1 (approximate to 170 nm), with outstanding fluorescent brightness (quantum yield approximate to 0.14%), performs accurate tracing of the lymphatic system as well as identification of vessel networks in mice brains with excellent signal-to-background ratio images. Meanwhile, rapidly excreted SCH4, showing fast and high passive liver tumor uptake and promising tumor/normal tissue ratios (>7), is capable of facilitating precise image-guided tumor surgery, and also demonstrates the first example of the assessment of liver fibrosis in the NIR-II window.
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