期刊
ACTA PAEDIATRICA
卷 105, 期 8, 页码 881-889出版社
WILEY
DOI: 10.1111/apa.13413
关键词
Amino acids; Glucose; Insulin; Intrauterine growth restriction; Oxygen
类别
资金
- NIH [T32 HD007186, K12 HD068372, R01 DK088139, K08 HD060688, R01HD079404, R03 DK102972, K01 DK090199, R01 DK084842]
- NIH Building Interdisciplinary Careers in Women's Health [K12 HD057022]
- University of Colorado Center for Women's Health Research
Previous attempts to improve growth and development of the intrauterine growth-restricted (IUGR) foetus during pregnancy have not worked or caused harm. Our research identifies tissue-specific mechanisms underlying foetal growth restriction and then tests strategies to improve growth and ameliorate many of the metabolic problems before the infant is born. The goal of our studies is to reduce the impact of foetal growth restriction at critical stages of development on the lifelong complications of IUGR offspring. Conclusion: Defining specific mechanisms that cause growth restriction in the foetus might identify specific nutrients and hormones that could be given to the mother to improve foetal growth and reduce metabolic complications, using strategies first tested in our IUGR animal model.
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