期刊
SCIENTIFIC REPORTS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41598-018-37194-2
关键词
-
资金
- Center for BioNano Health-Guard - Ministry of Science and ICT (MSIT) [H-GUARD_2014M3A6B2060507, H-GUARD_2013M3A6B2078950]
- Bio & Medical Technology Development Program of the National Research Foundation (NRF) - MSIT [NRF-2018M3A9E2022821]
- Basic Science Research Program of the NRF - MSIT [NRF-2018R1C1B6005424]
- KRIBB Research Initiative Program
- National Research Foundation of Korea [2018M3A9E2022821] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Peptidoglycan-binding protein-modified magnetic nanobeads (PGBP-MNBs) were prepared for efficient magnetic capturing of Staphylococcus aureus (S. aureus), which is associated with sepsis, using the binding affinity of PGBP for the peptidoglycan (PG) layer on S. aureus. These PGBP-MNBs can simply capture S. aureus in plasma within 1 hr or even 15 min. Importantly, they also can capture various types of Gram-positive bacteria, such as Bacillus cereus and methicillin-resistant and methicillin-susceptible S. aureus (MRSA and MSSA). We believe that PGBP-based systems will be used to develop diagnostic systems for Gram-positive bacteria-related diseases.
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