Red blood cell distribution width predicts prognosis in idiopathic sudden sensorineural hearing loss

Conclusion: Red cell distribution width (RDW) can predict outcome in patients with idiopathic sudden sensorineural hearing loss (ISSNHL). Further studies are required to clarify the potential pathophysiological explanations for these findings.Objectives: RDW is one of the parameters reported in a complete blood count, and is elevated in direct proportion to variation in red cell size (anisocytosis). High RDW values are strongly associated with poor clinical outcomes in various diseases, including inflammatory and thrombotic diseases. To identify a prognostic biomarker that better predicts outcomes after ISSNHL, the association between RDW values at hospitalization and prognosis in patients with ISSNHL was assessed.Method: This study measured RDW and performed hearing assessments in 89 consecutive patients with ISSNHL. Patients were then divided into two groups (recovered' and unrecovered'), according to their response to the treatment, and further analysis undertaken.Results: Mean RDW was significantly higher in the unrecovered group (13.2%+/- 1.0% compared with 12.7%+/- 0.7% in the recovered group, p=0.031). After adjusting for potentially confounding factors in a binary logistic regression model, only RDW was associated with recovery from ISSNHL (odds ratio =2.33, 95% confidence interval =1.20-4.51, p=0.012).