期刊
NUTRIENTS
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/nu11010168
关键词
vitamin K; CKD; vascular calcification
Vitamin K is a composite term referring to a group of fat-soluble vitamins that function as a cofactor for the enzyme gamma-glutamyl carboxylase (GGCX), which activates a number of vitamin K-dependent proteins (VKDPs) involved in haemostasis and vascular and bone health. Accumulating evidence demonstrates that chronic kidney disease (CKD) patients suffer from subclinical vitamin K deficiency, suggesting that this represents a population at risk for the biological consequences of poor vitamin K status. This deficiency might be caused by exhaustion of vitamin K due to its high requirements by vitamin K-dependent proteins to inhibit calcification.
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