期刊
NEUROSCIENCE BULLETIN
卷 35, 期 3, 页码 401-418出版社
SPRINGER
DOI: 10.1007/s12264-018-00331-y
关键词
Gait analysis; DigiGait; CatWalk; Neuropathic pain; Inflammatory pain; Analgesic
资金
- National Natural Science Foundation of China [31720103908, 31530028]
- National Key Technology Support Program of the Ministry of Science and Technology of China [2017YFA0701300]
Investigation of pain requires measurements of nociceptive sensitivity and other pain-related behaviors. Recent studies have indicated the superiority of gait analysis over traditional evaluations (e.g., skin sensitivity and sciatic function index [SFI]) in detecting subtle improvements and deteriorations in animal models. Here, pain-related gait parameters, whose criteria include (1) alteration in pain models, (2) correlation with nociceptive threshold, and (3) normalization by analgesics, were identified in representative models of neuropathic pain (spared nerve injury: coordination data) and inflammatory pain (intraplantar complete Freund's adjuvant: both coordination and intensity data) in the DigiGait and CatWalk systems. DigiGait had advantages in fixed speed (controlled by treadmill) and dynamic SFI, while CatWalk excelled in intrinsic velocity, intensity data, and high-quality 3D images. Insights into the applicability of each system may provide guidance for selecting the appropriate gait imaging system for different animal models and optimization for future pain research.
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