期刊
NEUROSCIENCE BULLETIN
卷 35, 期 3, 页码 551-560出版社
SPRINGER
DOI: 10.1007/s12264-018-0296-5
关键词
Pericytes; Brain; Blood vessel; Plasticity
资金
- Instituto Serrapilheira [Serra-1708-15285]
- Pro-reitoria de Pesquisa/Universidade Federal de Minas Gerais (PRPq/UFMG)
- National Institute of Science and Technology in Theranostics and Nanobiotechnology (CNPq/CAPES/FAPEMIG) [465669/2014-0]
- FAPEMIG [Rede Mineira de Engenharia de Tecidos e Terapia Celular (REMETTEC)] [RED-00570-16]
- FAPEMIG [Rede De Pesquisa Em Doencas Infecciosas Humanas E Animais Do Estado De Minas Gerais] [RED-00313-16]
- National Institute of Health [1R01CA179072-01A1]
- American Cancer Society Mentored Research Scholar Grant [124443-MRSG-13-121-01-CDD]
Cerebral pericytes are perivascular cells that stabilize blood vessels. Little is known about the plasticity of pericytes in the adult brain in vivo. Recently, using state-of-the-art technologies, including two-photon microscopy in combination with sophisticated Cre/loxP in vivo tracing techniques, a novel role of pericytes was revealed in vascular remodeling in the adult brain. Strikingly, after pericyte ablation, neighboring pericytes expand their processes and prevent vascular dilatation. This new knowledge provides insights into pericyte plasticity in the adult brain.
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