期刊
MATERIALS
卷 11, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/ma11102041
关键词
low-energy ultrasound; mesoporous silica; folic acid; rapid release; chemo-sonodynamic therapy
类别
资金
- National Natural Science Foundation of China [51572283, 51072217, 51232007]
- Science and Technology Commission of Shanghai Municipality [08JC1420700, 11XD1405600]
- Shanghai Sailing Program [17YF1421700]
- Innovation Fund of SICCAS [Y75ZC8180G]
Low-energy ultrasound (LEUS), exhibiting obvious advantages as a safe therapeutic strategy, would be promising for cancer therapy. We had synthesized a LEUS-responsive targeted drug delivery system based on functional mesoporous silica nanoparticle for cancer therapy. Paclitaxel (PTX) was loaded in mesoporous silica nanoparticles with a hydrophobic internal channel, and folic acid (FA) functionalized -Cyclodextrin (-CD) was capped on the surface of the nanoparticles (DESN), which acted as a cancer-targeting moiety and solubilizer. The existence of a hydrophobic internal channel in the DESN was beneficial to the storage of hydrophobic PTX, along with the enhancement of the cavitation effect produced by mild low-energy ultrasound (LEUS, 1.0 W/cm(2), 1 MHz). The DESN showed significantly enhanced cavitation effect, selective targeting, and achieved a rapid drug release under mild LEUS. To investigate the in vivo antitumor efficacy of the DESN upon LEUS irradiation, we established a 4T1 mammary tumor model. The DESN were confirmed to be of great biodegradability/biocompatibility. The tumor growth was significantly inhibited when the mice were treated with DESN (10 mg/kg) + LEUS with the relative tumor volume reduced to 4.72 +/- 0.70 compared with the control group (V/V-0 = 17.12 +/- 2.75). The DESN with LEUS represented excellent inhibiting effect on tumor cell in vivo. This work demonstrated that DESN mediating dual mode chemo-sonodynamic therapy could be triggered by extracorporeal remote control, may suggest a promising clinical application in cancer therapy.
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