期刊
INTERNATIONAL JOURNAL OF OPHTHALMOLOGY
卷 12, 期 1, 页码 152-160出版社
IJO PRESS
DOI: 10.18240/ijo.2019.01.22
关键词
glaucoma; retinal ganglion cells; induced pluripotent stem cells; differentiation
资金
- 555 Talent Plan Grant from the Changsha National High-Tech Industrial Development Zoom
Glaucoma is a common optic neuropathy that is characterized by the progressive degeneration of axons and the loss of retinal ganglion cells (RGCs). Glaucoma is one of the leading causes of irreversible blindness worldwide. Current glaucoma treatments only slow the progression of RGCs loss. Induced pluripotent stem cells (iPSCs) are capable of differentiating into all three germ layer cell lineages. iPSCs can be patient-specific, making iPSC-derived RGCs a promising candidate for cell replacement. In this review, we focus on discussing the detailed approaches used to differentiate iPSCs into RGCs.
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