期刊
DIABETOLOGY & METABOLIC SYNDROME
卷 11, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13098-018-0398-2
关键词
Metabolic syndrome; Cohort studies; Neoplasm; Mortality; Japanese
资金
- Foundation for the Development of the Community, Tochigi, Japan
- Comprehensive Research on Cardiovascular and Life-Style Related Diseases [H26-Junkankitou [Seisaku]-Ippan-001]
BackgroundMetabolic syndrome (MetS) and cancer are major public health problems worldwide. The relationship between MetS and cancer death is of great interest. We examined the predictive value of MetS for cancer mortality in Japan.MethodsStudy participants included 4495 men and 7028 women aged 18-90years who were registered between 1992 and 1995 as part of the Jichi Medical School Cohort Study. We used a definition of MetS modified for the Japanese population. The primary outcome was cancer mortality. Additionally, the relationship between MetS and cancer-type specific mortality was examined. Analyses were conducted with Cox's regression models adjusted for age, smoking status, alcohol drinking status, marital status, educational attainment, physical activity, occupational category, and menopausal status (only in women).ResultsDuring a mean follow-up of 18.5years, 473 men and 297 women died from cancer. MetS was positively associated with cancer mortality in women (hazard ratio [HR], 1.69; 95% confidence interval [CI] 1.21-2.36), but not in men (HR, 1.21; 95% CI 0.90-1.62). Additionally, MetS was associated with a high risk of colorectal (HR, 3.48; 95% CI 1.68-7.22) and breast (HR, 11.90; 95% CI 2.25-62.84) cancer deaths in women.ConclusionMetS was a significant predictor of cancer mortality in women.
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