Clinical evaluation of prophylactic abdominal aortic balloon occlusion in patients with placenta accreta: a systematic review and meta-analysis

BackgroundSevere obstetric hemorrhage caused by placenta accreta results in significant maternal morbidity and mortality. As a new technology, abdominal aortic balloon occlusion (AABO) is becoming an important treatment for patients with placenta accreta. To evaluate the safety and efficacy of AABO, we conducted a systematic review and meta-analysis of previous studies.MethodsWe used a three-check subset including placenta accreta (placenta previa, percreta, increta, etc.), balloon, and aortic (aortas, aorta, etc.) to form a retrieval formula and searched in MEDLINE, EMBASE, the Cochrane Library, clinicaltrials.gov and Web of Science. All articles regarding placenta previa or placenta accreta and including the use of abdominal aortic balloon occlusion were included in our screening. Two researchers selected articles and extracted data independently. Finally, the Newcastle-Ottawa Quality Assessment Scale was used for quality assessments.ResultsWe retrieved 776 articles and eventually included 11 clinical studies. Meta-analysis showed that AABO significantly reduced the blood loss volume (MD-1480ml, 95% CI -1806 to-1154ml, P<0.001) and blood transfusion volume (MD-1125ml, 95% CI -1264 to-987ml, P<0.001). Similarly, obvious reductions in the hysterectomy rate (OR 0.30, 95% CI 0.19 to 0.48, P<0.001), hospitalization duration (MD-1.35days, 95% CI -2.40 to-0.31days, P=0.01), and operative time (MD-29.23min, 95% CI -46.04 to-12.42min, P<0.001) were observed in the AABO group.ConclusionThe prophylactic use of AABO in patients with placenta accreta is safe and effective.