期刊
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
卷 9, 期 -, 页码 3079-3094出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjnano.9.286
关键词
nanomaterials safety; biomaterials; tissue engineering; microscopic characterization; cytotoxicity; hydroxyapatite
资金
- People Programme scientific exchange (Marie Curie Actions) of the European Union Seventh Framework Programme FP7/2007-2013/ under REA [295128]
- National Science Centre of Poland [UMO-2011/01/B/ST8/07559]
Nanomaterials, such as hydroxyapatite nanoparticles show a great promise for medical applications due to their unique properties at the nanoscale. However, there are concerns about the safety of using these materials in biological environments. Despite a great number of published studies of nanoobjects and their aggregates or agglomerates, the impact of their physicochemical properties (such as particle size, surface area, purity, details of structure and degree of agglomeration) on living cells is not yet fully understood. Significant differences in these properties, resulting from different manufacturing methods, are yet another problem to be taken into consideration. The aim of this work was to investigate the correlation between the properties of nanoscale hydroxyapatite from different synthesis methods and biological activity represented by the viability of four cell lines: A549, CHO, BEAS-2B and J774.1 to assess the influence of the nanoparticles on immune, reproductive and respiratory systems.
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