期刊
ACS CATALYSIS
卷 9, 期 2, 页码 1457-1463出版社
AMER CHEMICAL SOC
DOI: 10.1021/acscatal.8b04787
关键词
asymmetric catalysis; hydrophosphination; chiral phosphine; alkene; ligand design
资金
- Shenzhen Basic Research Program [JCYJ20170817112532779, JCYJ20170412152435366]
- Shenzhen Nobel Prize Scientists Laboratory Project [C17213101]
Asymmetric hydrophosphination is the most atomically economical and straightforward approach to the construction of chiral organophosphorus compounds. Good stereoselectivities have been achieved in asymmetric hydrophosphination of an electron-deficient C=C double bond, but substrates involving nonpolar C=C bonds remain difficult and are rarely tackled. Herein, we report asymmetric hydrophosphination of a non-electronically activated double bond with a remarkably high degree of stereocontrol. This strategy offered an expedient and broadly applicable platform to prepare tertiary phosphines in high yields (up to 99% yield) and enantioselectivities (up to 99% ee). Particularly noteworthy is that these tertiary phosphine products were then successfully employed as phosphine ligands in enantioselective metal-catalyzed transformations with a high level of asymmetric induction.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据