期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-07405-5
关键词
-
资金
- Natural Science Foundation of China [81788101, 81761128013, 81571522, 91642105, 91542114, 91542000]
Natural killer (NK) cells are reported to have immunological memory, with CD49 alpha(+) liver-resident NK cells shown to confer hapten-specific memory responses, but how this memory is induced or maintained is unclear. Here we show that memory type I innate lymphoid cells (ILC1s), which express IL-7R alpha, are generated in the lymph nodes (LNs) and require IL-7R signaling to maintain their longevity in the liver. Hapten sensitization initiates CXCR3-dependent recruitment of IL-7R alpha(+) ILC1s into skin-draining LNs, where they are primed and acquire hapten-specific memory potential. Memory IL-7R alpha(+) ILC1s then exit draining LNs and are preferentially recruited, via CXCR6, to reside in the liver. Moreover, long-term blockade of IL-7R signaling significantly reduces ILC1-mediated memory responses. Thus, our results identify a memory IL-7R alpha(+) ILC1 population and reveal a LN-liver axis that is essential for ILC1 memory generation and long-term maintenance.
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