期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-07946-9
关键词
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资金
- National Academies of Sciences, Engineering, and Medicine Ford Foundation Predoctoral Fellowship
- Howard Hughes Medical Institute Gilliam Fellowship
- Defense Advanced Research Projects Agency [HR0011515303, HR0011-15-C-0091]
- U.S. Department of Energy [DE-SC0004962, DE-SC0012627]
- NIH [5R01DE024468, R01GM121950, Sub_P30DK036836_PF]
- National Science Foundation [1457695, NSFOCE-BSF 1635070]
- MURI Grant [W911NF-12-1-0390]
- Human Frontiers Science Program [RGP0020/2016]
- Boston University Inter-disciplinary Biomedical Research Office
- U.S. Department of Energy (DOE) [DE-SC0012627, DE-SC0004962] Funding Source: U.S. Department of Energy (DOE)
Metabolic exchange mediates interactions among microbes, helping explain diversity in microbial communities. As these interactions often involve a fitness cost, it is unclear how stable cooperation can emerge. Here we use genome-scale metabolic models to investigate whether the release of costless metabolites (i.e. those that cause no fitness cost to the producer), can be a prominent driver of intermicrobial interactions. By performing over 2 million pairwise growth simulations of 24 species in a combinatorial assortment of environments, we identify a large space of metabolites that can be secreted without cost, thus generating ample cross-feeding opportunities. In addition to providing an atlas of putative interactions, we show that anoxic conditions can promote mutualisms by providing more opportunities for exchange of costless metabolites, resulting in an overrepresentation of stable ecological network motifs. These results may help identify interaction patterns in natural communities and inform the design of synthetic microbial consortia.
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