期刊
NATURE COMMUNICATIONS
卷 10, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-08005-z
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资金
- Japan Society for the Promotion of Science (JSPS) [17F17085, 15K21721, 15H04243, 18H03918]
- Japan Society for the Promotion of Science
- National Cancer Institute of the National Institutes of Health [R01CA045424]
- Research Excellence Fund (REF) from Center for Biomedical Research (CBR) at Oakland University
- Grants-in-Aid for Scientific Research [15H04243, 17F17085] Funding Source: KAKEN
Damage to DNA via dissociative electron attachment has been well-studied in both the gas and condensed phases; however, understanding this process in bulk solution at a fundamental level is still a challenge. Here, we use a picosecond pulse of a high energy electron beam to generate electrons in liquid diethylene glycol and observe the electron attachment dynamics to ribothymidine at different stages of electron relaxation. Our transient spectro-scopic results reveal that the quasi-free electron with energy near the conduction band effectively attaches to ribothymidine leading to a new absorbing species that is characterized in the UV-visible region. This species exhibits a nearly concentration-independent decay with a time constant of similar to 350 ps. From time-resolved studies under different conditions, combined with data analysis and theoretical calculations, we assign this intermediate to an excited anion radical that undergoes N1-C1' glycosidic bond dissociation rather than relaxation to its ground state.
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