期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-07875-7
关键词
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资金
- Biotechnology and Biological Sciences Research Council [BB/M020568/1, BB/M007820/1, BB/M002268/1, BB/M024458/1]
- European Research Council grant (ERC Starting Grant) [715441-GasPlaNt]
- NWO-ALW programme Graduate school Horticulture and Starting materials [EPS2 3c 195]
- BBSRC [BB/M002268/1, BB/M020568/1, BB/M007820/1, BB/M024458/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/M007820/1] Funding Source: researchfish
The polycomb repressive complex 2 (PRC2) regulates epigenetic gene repression in eukaryotes. Mechanisms controlling its developmental specificity and signal-responsiveness are poorly understood. Here, we identify an oxygen-sensitive N-terminal (N-) degron in the plant PRC2 subunit VERNALIZATION(VRN) 2, a homolog of animal Su(z) 12, that promotes its degradation via the N-end rule pathway. We provide evidence that this N-degron arose early during angiosperm evolution via gene duplication and N-terminal truncation, facilitating expansion of PRC2 function in flowering plants. We show that proteolysis via the N-end rule pathway prevents ectopic VRN2 accumulation, and that hypoxia and long-term cold exposure lead to increased VRN2 abundance, which we propose may be due to inhibition of VRN2 turnover via its N-degron. Furthermore, we identify an overlap in the transcriptional responses to hypoxia and prolonged cold, and show that VRN2 promotes tolerance to hypoxia. Our work reveals a mechanism for post-translational regulation of VRN2 stability that could potentially link environmental inputs to the epigenetic control of plant development.
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