期刊
NATURE COMMUNICATIONS
卷 9, 期 -, 页码 -出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/s41467-018-07578-z
关键词
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资金
- Virginia and D.K. Ludwig Fund for Cancer Reserach
- Sol Goldman Sequencing Facility at Johns Hopkins
- Johns Hopkins Clinician Scientist Award
- Burroughs Wellcome Career Award for Medical Scientists
- Doris Duke Charitable Foundation [2014107]
- Department of Neurosurgery
- SPORE [P50 CA062924]
Olfactory neuroblastoma (ONB) is a rare malignant neoplasm arising in the upper portion of the sinonasal cavity. To better understand the genetic bases for ONB, here we perform whole exome and whole genome sequencing as well as single nucleotide polymorphism array analyses in a series of ONB patient samples. Deletions involving the dystrophin (DMD) locus are found in 12 of 14 (86%) tumors. Interestingly, one of the remaining tumors has a deletion in LAMA2, bringing the number of ONBs with deletions of genes involved in the development of muscular dystrophies to 13 or 93%. This high prevalence implicates an unexpected functional role for genes causing hereditary muscular dystrophies in ONB.
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