期刊
ONCOLOGY LETTERS
卷 17, 期 1, 页码 1279-1291出版社
SPANDIDOS PUBL LTD
DOI: 10.3892/ol.2018.9707
关键词
gastric cancer; lncRNA; Gene Set Enrichment Analysis; weighted gene co-expression network analysis; LL22NC03-N14H11; 1; LINC00982; survival analysis; proliferation
类别
Long non-coding RNAs (lncRNAs) have been generally considered to serve important roles in various types of cancer, including gastric cancer. However, a comprehensive understanding of lncRNAs in gastric cancer requires further study. The present study performed an in-depth study revealed 50 differently expressed lncRNAs. The changed cellular pathways and biological process in gastric cancer were determined. To further confirm the functions of the differently expressed lncRNAs, co-expression networks were constructed between the lncRNAs and mRNA; this lead to the identification of 6 modules, which participated in various cellular pathways. In addition, 2 lncRNAs were identified which were associated with clinical outcome. The biological analysis and experimental evidence suggested that LINC00982 inhibited, while LL22NC03-N14H11.1 promoted the proliferation of gastric cancer cells. These lncRNAs may be considered as potential prognostic factor in gastric cancer.
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