期刊
JOURNAL OF FUNCTIONAL FOODS
卷 52, 期 -, 页码 34-42出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jff.2018.10.029
关键词
beta-hydroxy-beta-methyl butyrate; Protein synthesis; Protein degradation; Akt; Skeletal muscle; Growing pigs
资金
- Youth Innovation Promotion Association CAS [2016326]
- Guangdong Province Key Laboratory of Animal Nutritional Regulation [DWYYTK-18KF002]
- Science and Technology Projects of Hunan Province [2016SK3022, 2017RS3058]
- Key Project of Research and Development Plan of Hunan Province [2016NK2170]
- National Key RD Program [2016YFD0501204]
- Earmarked Fund for China Agriculture Research System [CARS-35]
- Guangdong Academy of Science [2017GDASCX-0702]
- Major Project for Changsha City [kq1706147]
- Youth Innovation Team Project of ISA [2017QNCXTDZCS]
- Special Fund for Ability Construction
This study aimed to investigate the effects of leucine (Leu) and its metabolites (alpha-ketoisocaproate (KIC) and beta-hydroxy-beta-methylbutyrate (HMB)) on muscle protein metabolism in growing pigs fed low-protein diets. 32 pigs (Large White x Landrace, 9.55 +/- 0.19 kg) were divided into four groups (basal diet, L-Leu, KIC-Ca, HMB-Ca). Results showed that compared to the control, dietary supplementation of KIC and excess Leu significantly decreased the weight of soleus muscle (SM, P < 0.05), whereas HMB supplementation increased it, accompanied by elevated rate of protein synthesis and elevated phosphorylation of Akt (P < 0.05). The weight of longissimus dorsi muscle remained unaffected by dietary treatments (P > 0.05). In conclusion, HMB, but not KIC or excess Leu, might act as a nutrient signal to stimulate positive protein balance especially in muscles of oxidative fiber-types of growing pigs fed low-protein diets, and these effects might be associated with the Akt signaling.
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