期刊
BREAST CANCER
卷 26, 期 3, 页码 265-271出版社
SPRINGER JAPAN KK
DOI: 10.1007/s12282-018-00935-2
关键词
Breast cancer; TLR4; Metastasis
资金
- Rafsanjan University of Medical Sciences
Toll-like receptors (TLRs) may play dual roles in human cancers. TLR4 is a key molecule which may participate in both friend and foe roles against breast cancer. This review article collected recent data regarding the mechanisms used by TLR4 in the eradication of breast cancer cells and induction of the tumor cells, and discussed the mechanisms involved in the various functions of TLR4. The literature searches revealed that TLR4 is a key molecule that participates in breast cancer cell eradication or induction of breast cancer development and also transformation of the normal cells. TLR4 eradicates breast cancer cells via recognition of their DAMPs and then induces immune responses. Over-expression of TLR4 and also alterations in its signaling, including association of some intrinsic pathways such as TGF- signaling and TP53, are the crucial factors to alter TLR4 functions against breast cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据