期刊
VIRUSES-BASEL
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v11010010
关键词
bacteriophage; immunology; innate immunity; adaptive immunity; human host; phage-human host interaction
类别
资金
- National Science Centre in Poland [UMO-2012/05/E/NZ6/03314, UMO-2015/18/M/NZ6/00412]
- Australia Research Council Discovery Early Career Researcher Award [DE170100525]
- Australian Government
- Stanford SPARK
- Falk Medical Research Trust
- Cystic Fibrosis Foundation (CFF)
- [R21AI133370]
- [R21AI133240]
- [R01AI12492093]
- Australian Research Council [DE170100525] Funding Source: Australian Research Council
The human body is host to large numbers of bacteriophages (phages)-a diverse group of bacterial viruses that infect bacteria. Phage were previously regarded as bystanders that only impacted immunity indirectly via effects on the mammalian microbiome. However, it has become clear that phages also impact immunity directly, in ways that are typically anti-inflammatory. Phages can modulate innate immunity via phagocytosis and cytokine responses, but also impact adaptive immunity via effects on antibody production and effector polarization. Phages may thereby have profound effects on the outcome of bacterial infections by modulating the immune response. In this review we highlight the diverse ways in which phages interact with human cells. We present a computational model for predicting these complex and dynamic interactions. These models predict that the phageome may play important roles in shaping mammalian-bacterial interactions.
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