期刊
VIRUSES-BASEL
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v11010074
关键词
Middle East respiratory syndrome coronavirus; severe acute respiratory syndrome coronavirus; coronavirus spike glycoprotein; vaccine platforms; correlates of immunity; animal models
类别
资金
- National Institute of Allergy & Infectious Disease
- National Institute of Aging of the NIH [U19AI100625, R00AG049092]
- McLaughlin Endowment through the Institute of Human Infection and Immunity at the University of Texas Medical Branch
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI100625] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R00AG049092] Funding Source: NIH RePORTER
Efforts towards developing a vaccine for Middle East respiratory syndrome coronavirus (MERS-CoV) have yielded promising results. Utilizing a variety of platforms, several vaccine approaches have shown efficacy in animal models and begun to enter clinical trials. In this review, we summarize the current progress towards a MERS-CoV vaccine and highlight potential roadblocks identified from previous attempts to generate coronavirus vaccines.
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