期刊
VIRUSES-BASEL
卷 11, 期 1, 页码 -出版社
MDPI
DOI: 10.3390/v11010060
关键词
Coronavirus; MERS-CoV; spike protein; receptor-binding domain; vaccines; therapeutics
类别
资金
- NSFC [81571983]
- NIH [R21AI128311, R01AI137472, R01AI139092]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI139092, R21AI128311, R01AI137472] Funding Source: NIH RePORTER
Middle East respiratory syndrome (MERS) coronavirus (MERS-CoV) is an infectious virus that was first reported in 2012. The MERS-CoV genome encodes four major structural proteins, among which the spike (S) protein has a key role in viral infection and pathogenesis. The receptor-binding domain (RBD) of the S protein contains a critical neutralizing domain and is an important target for development of MERS vaccines and therapeutics. In this review, we describe the relevant features of the MERS-CoV S-protein RBD, summarize recent advances in the development of MERS-CoV RBD-based vaccines and therapeutic antibodies, and illustrate potential challenges and strategies to further improve their efficacy.
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