期刊
VIRUSES-BASEL
卷 10, 期 10, 页码 -出版社
MDPI
DOI: 10.3390/v10100558
关键词
Oncolytic adenovirus; extracellular vesicles; lung cancer; immunocompetent mouse model; in vivo imaging
类别
资金
- Post doc pool foundation [016947-3]
- Italian Association for Cancer Research [IG-11903]
- MIUR (Departments of excellence Italian Law) [232]
Oncolytic viruses (OV) are engineered to infect, replicate in and kill cancer cells. Currently, the OV therapeutic approach is mainly restricted to neoplasia amenable to direct local administration of viral particles, while the possibility of a systemic delivery of cancer-tropic viruses would extend the OV application to the treatment of metastatic neoplasia. Herein, we applied in vivo/ex vivo imaging to demonstrate that cancer tropism is achieved when OV are encapsulated inside extracellular vesicles (EV) administered intravenously (i.v.), but not when injected intraperitoneally (i.p.). Moreover, we show that the therapeutic procedure adopted does not alter the immunomodulatory properties of the viruses.
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