期刊
WORLD JOURNAL OF SURGICAL ONCOLOGY
卷 16, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12957-018-1494-3
关键词
Radiofrequency ablation; Resection; Liver metastasis; Colorectal cancer; Survival
资金
- National Nature Science Foundation of China [81371868]
- Beijing Municipal Science & Technology Commission [Z151100004015186]
BackgroundLiver resection is the first-line treatment for patients with resectable colorectal liver metastasis (CRLM), while radiofrequency ablation (RFA) can be used for small unresectable CRLM because of disease extent, poor anatomical location, or comorbidities. However, the long-term outcomes are unclear for RFA treatment in resectable CRLM. This study aimed to compare the recurrence rates and prognosis between resectable CRLM patients receiving either liver resection or RFA.MethodsConsecutive patients who underwent RFA or hepatic resection from November 2010 to December 2015 were assigned in this retrospective study. Propensity score analysis was used to eliminate baseline differences between groups. Survival and recurrence rates were compared between patients receiving liver resection and RFA.ResultsWith 1:2 ratio of propensity scoring, 46 patients in the RFA group and 92 in the resection group were successfully matched. Overall survival was similar between the two groups, but the resection group had a higher disease-free survival (median, 22months vs. 14months). Whereas among patients with a tumor size of 3cm, disease-free survival was similar in the two groups (median, 24months vs. 21months). Compared to the resection group, the RFA group had a higher rate of intrahepatic recurrence (34.8% vs. 12.0%) and a shorter recurrence free period. The local and systemic recurrence rate and recurrence-free period for the same were insignificant in the two groups. Poor disease-free survival was associated with RFA, T4, tumor diameter >3cm, and lymph node positivity.ConclusionAmong patients with technically resectable CRLM, resection provided greater disease-free survival, although both treatment modalities provided similar overall survival.
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