期刊
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
卷 34, 期 12, 页码 -出版社
SPRINGER
DOI: 10.1007/s11274-018-2561-1
关键词
Transcriptome; Saccharomyces cerevisiae; Ethanol stress; Cyclocarya paliurus; Triterpenoids
资金
- Key Research and Development Project of Zhejiang Province [2017C02039, 2018C02047]
- People-benefit Project of Ningbo [2015C10061]
- K.C. Wong Magna Fund in Ningbo University
Saccharomyces cerevisiae (S. cerevisiae) plays a critical role in ethanol fermentation. However, during the fermentation, yeast cells are exposed to the accumulation of ethanol, which significantly affect the cell growth and the target product yield. In the present work, we employed RNA-sequence (RNA-seq) to investigate the ameliorate effect of Cyclocarya paliurus (C. paliurus) triterpenoids on S. cerevisiae under the ethanol stress. After C. paliurus triterpenoids intervention (0.3% v/ v), 84 differentially expressed genes (DEGs) were identified, including 39 up-regulated and 45 down-regulated genes. The addition of triterpenoids decreased the filamentous and invasive growth of cells, and benefit to the redox balance and glycolysis. This study offers a global view through transcriptome analysis to understand the molecular response to ethanol in Sc131 by the treatment of C. paliurus triterpenoids, which may be helpful to enhance ethanol tolerance of S. cerevisiae in the fermentation of Chinese fruit wine. [GRAPHICS] .
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