期刊
WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
卷 21, 期 10, 页码 784-789出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/15622975.2018.1563721
关键词
Cocaine use disorders; crack; HTR2B gene; impulsivity; ADHD
类别
资金
- Centre National de la Recherche Scientifique
- Institut National de la Sante et de la Recherche Medicale
- Fondation pour la Recherche sur le Cerveau
- Fondation pour la Recherche Medicale [Equipe FRM DEQ2014039529]
- French Ministry of Research (Agence Nationale pour la Recherche) [ANR-17-CE16-0008]
- French Ministry of Research (Investissements d'Avenir programme) [ANR-11-IDEX-0004-02]
- French state funds by the ANR within the Investissements d'Avenir programme [ANR-11-IDEX-0004-02]
- University Hospital of Martinique
- Clinical Research and Innovation Unit (DRCI) of the University Hospital of Martinique
- Sorbonne Universites
Objectives: Cocaine dependence has a strong heritability component. The aim of this study was to investigate the putative association between the serotonin 2B receptor gene (HTR2B), crack use disorders and impulsivity. Methods: A French Afro-Caribbean male population of patients with crack use disorders (n = 80) was compared to healthy Afro-Caribbean male controls (n = 60). Comorbid ADHD and impulsivity were assessed. Five single nucleotide polymorphisms (SNPs) in the HTR2B gene were selected: rs643700, rs6736017, rs1549339, rs17586428 and rs3806545. These SNPs were chosen to include most of the linkage disequilibrium blocks in the HTR2B gene. The French translation of the Barratt Impulsivity Scale BIS-11 was used to evaluate impulsivity. Comorbid ADHD was diagnosed using the Wender Utah Rating Scale-25 item for Attention Deficit-Hyperactivity Disorder. Results: We have observed a positive association between the rs6736017 polymorphism and crack use disorders in a French Afro-Caribbean male population. Conclusions: In our population, the risk effect of HTR2B rs6736017 appeared to be specific to individuals with crack use disorders rather than being driven by impulsivity or ADHD alone.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据