期刊
VIROLOGY JOURNAL
卷 15, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s12985-018-1082-8
关键词
Hepatitis E virus; HEV genotype 2; HEV subtype 2b; Outbreak; Nigeria; Complete genome
类别
资金
- Global Outbreak Alert and Response Network (GOARN) Program of the World Health Organisation (WHO)
- German Academic Exchange Service (DAAD), Bonn, Germany
- Global Health Protection Programme - Federal Ministry of Health
- China Scholarship Council (CSC), Beijing, China
- Claussen-Simon-Stiftung (Claussen-Simon Foundation) Dissertation Plus program, Germany
- Partnership in Postgraduate Education (PPE), Robert Koch Institute, Berlin, Germany
BackgroundIn 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail.FindingThe full-length genome sequence of an HEV-2 strain (NG/17-0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17-0500 belongs to HEV subtype 2b (HEV-2b).ConclusionsWe identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation.
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