期刊
ACTA NEUROLOGICA SCANDINAVICA
卷 136, 期 2, 页码 129-137出版社
WILEY
DOI: 10.1111/ane.12707
关键词
carbamate; National Health Insurance Research Database; organophosphate; Parkinson disease
资金
- Taiwan Ministry of Health and Welfare Clinical Trial and Research Center of Excellence [MOHW105-TDU-B-212-133019]
- China Medical University Hospital
- Academia Sinica Taiwan Biobank Stroke Biosignature Project [BM10501010037]
- National Research Program for Biopharmaceuticals Stroke Clinical Trial Consortium [MOST105-2325-B-039-003]
- Tseng-Lien Lin Foundation
- Taiwan Brain Disease Foundation
- Katsuzo and Kiyo Aoshima Memorial Funds
- China Medical University
- Ministry of Education
AimsParkinson disease (PD) is a common neurodegenerative disease. The aim of this study was to evaluate the risk of PD in patients with organophosphate (OP) or carbamate (CM) poisoning by using the Taiwan National Health Insurance Research Database. MethodsWe conducted a retrospective study involving a cohort of 45594 patients (9128 patients with a history of OP or CM poisoning and 36466 control patients) who were selected from the Taiwan National Health Insurance Research Database. The patients were observed for a maximum of 12years to determine the rates of new-onset PD, and a Poisson regression model was used to identify the predictors of PD. The cumulative incidence of PD between the two cohorts was plotted through Kaplan-Meier analysis. ResultsDuring the study period, the incidence rate ratio (IRR) of PD in the OP or CM poisoning patients was 1.36-fold [95% confidence interval (CI)=1.26-1.47] higher than that in the control patients in the multivariable model. The absolute incidence of PD was the highest for the group aged 75years in both cohorts (77.4 vs 43.7 per 10000 person-years). However, the age-specific relative risk was higher for the group aged <50years (adjusted IRR=3.88; 95% CI=3.44-4.39). ConclusionOur results suggest that the likelihood of developing PD is greater in patients with OP or CM poisoning than in those without poisoning. OP or CM poisoning may be an independent risk factor for PD.
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