4.0 Article

Age, Sex, and Genetic and Environmental Effects on Unintentional Injuries in Young and Adult Twins

期刊

TWIN RESEARCH AND HUMAN GENETICS
卷 21, 期 6, 页码 502-506

出版社

CAMBRIDGE UNIV PRESS
DOI: 10.1017/thg.2018.61

关键词

injuries; genetics; environmental effects; twins

资金

  1. National Institute of Alcohol Abuse and Alcoholism [AA-12502, AA-00145, AA-09203]
  2. Academy of Finland [265240, 263278, 100499, 205585, 118555]
  3. Academy of Finland Centre of Excellence in Complex Disease Genetics [213506, 129680]

向作者/读者索取更多资源

The aim of this study was to examine the effects of genetic and environment influences and sex on injury involvement using two sets of Finnish twin data. The younger participants were 955 twins born between 1983 and 1987, aged 20 to 24 years. The older participants were 12,428 twins born between 1930 and 1957, aged 33 to 60 years. Within-twin correlations in monozygotic and dizygotic twins suggested that genetic effects play no role in injury involvement among young twins, but do have some effect at older ages. The results indicated that environmental factors have greater importance in injury involvement than genetic factors in the younger twin data set (FT12), whereas in a middle-aged (33-60 years) twin data set, genetic effects explained about quarter of the variance in injury involvement. Sex was a strong contributing factor, with males being generally more prone to injuries than females.

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