期刊
TRIALS
卷 20, 期 -, 页码 -出版社
BMC
DOI: 10.1186/s13063-018-3113-6
关键词
Longitudinal; Multi-centre; Magnetic resonance imaging; Study design; Data sharing; Guidelines; Big data
资金
- Medical Research Council [G0701120, G1001245, MR/M013111/1]
- Wellcome Trust [075611, WT088134/Z/09/A]
- Age UK
- Lupus UK
- Stroke Association [TSA02/01]
- Chest Heart and Stroke Scotland [ResFell04]
- Row Fogo Charitable Trust [BRO-D.FID3668413]
- Scottish Funding Council through the SINAPSE Collaboration (Scottish Imaging Network-A Platform for Scientific Evidence)
- Chief Scientist Office [CZB/4/281]
- Alzheimer's Society
- MRC [MR/R024065/1, G0701120, MR/M013111/1, G1001245, UKDRI-4002] Funding Source: UKRI
- Medical Research Council [MR/R024065/1, MR/M013111/1, G0701120, G1001245] Funding Source: researchfish
BackgroundResearch involving brain imaging is important for understanding common brain diseases. Study endpoints can include features and measures derived from imaging modalities, providing a benchmark against which other phenotypical data can be assessed. In trials, imaging data provide objective evidence of beneficial and adverse outcomes. Multi-centre studies increase generalisability and statistical power. However, there is a lack of practical guidelines for the set-up and conduct of large neuroimaging studies.MethodsWe address this deficit by describing aspects of study design and other essential practical considerations that will help researchers avoid common pitfalls and data loss.ResultsThe recommendations are grouped into seven categories: (1) planning, (2) defining the imaging endpoints, developing an imaging manual and managing the workflow, (3) performing a dummy run and testing the analysis methods, (4) acquiring the scans, (5) anonymising and transferring the data, (6) monitoring quality, and (7) using structured data and sharing data.ConclusionsImplementing these steps will lead to valuable and usable data and help to avoid imaging data wastage.
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