期刊
TRENDS IN NEUROSCIENCES
卷 42, 期 2, 页码 102-114出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2018.10.002
关键词
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资金
- EMBO Long-Term Postdoctoral Fellowship [ALTF 382-2017]
- Sir Henry Wellcome Postdoctoral Fellowship [206491/Z/17/Z, 209120/Z/17/Z]
- Medical Research Council in the UK [MC_UU_12024/1]
- Novo Nordisk Foundation Young Investigator Award 2017 [NNF17OC0026774]
- Aarhus Institute of Advanced Studies (AIAS)-EU FP7 Cofund programme [754513]
- Lundbeckfonden [DANDRITE-R248-2016-2518]
- Branco Weiss - Society in Science Fellowship
- Radboud Excellence Initiative
- Christine Mohrmann Fellowship
- Wellcome Trust [209120/Z/17/Z, 206491/Z/17/Z] Funding Source: Wellcome Trust
- MRC [MC_UU_12024/1] Funding Source: UKRI
Adaptation to the ever-changing world is critical for survival, and our brains are particularly tuned to remember events that differ from previous experiences. Novel experiences induce dopamine release in the hippocampus, a process which promotes memory persistence. While axons from the ventral tegmental area (VTA) were generally thought to be the exclusive source of hippocampal dopamine, recent studies have demonstrated that noradrenergic neurons in the locus coeruleus (LC) corelease noradrenaline and dopamine in the hippocampus and that their dopamine release boosts memory retention as well. In this opinion article, we propose that the projections originating from the VTA and the LC belong to two distinct systems that enhance memory of novel events. Novel experiences that share some commonality with past ones ('common novelty') activate the VTA and promote semantic memory formation via systems memory consolidation. By contrast, experiences that bear only a minimal relationship to past experiences ('distinct novelty') activate the LC to trigger strong initial memory consolidation in the hippocampus, resulting in vivid and long-lasting episodic memories.
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