期刊
TRENDS IN IMMUNOLOGY
卷 39, 期 11, 页码 874-889出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.09.005
关键词
-
类别
资金
- Naito Foundation
- SENSHIN Medical Research Foundation
- Yakult Bio-Science Foundation
- Smoking Research Foundation
- Kobayashi Foundation for Cancer Research
- Takeda Science Foundation
- Japan Agency for Medical Research and Development (AMED) Grants for Research on Intractable Diseases
Autoimmune pancreatitis (AIP) is a pancreatic manifestation of a recently defined disease form known as IgG4-related disease (AIP/IgG4-RD). AIP/IgG4-RD is characterized by elevated systemic IgG4 antibody concentrations and lesional tissues infiltrated by IgG4-expressing plasmacytes. In addition, recent studies have revealed that, in common with other autoimmune diseases, such as systemic lupus erythematosus (SLE) and psoriasis, AIP/IgG4-RD is associated with increased type I IFN (IFN-I) production by plasmacytoid dendritic cells (pDCs). However, unlike SLE, AIP/IgG4-RD is characterized by elevated IFN-I-dependent IL-33 production, the latter emerging as an important contributor to inflammation and fibrotic responses characterizing this disease. On this basis, we propose that blockade of the IFN-I/IL-33 axis might constitute a successful approach to treating this unique type of autoimmunity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据