期刊
TRENDS IN IMMUNOLOGY
卷 40, 期 2, 页码 128-141出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.it.2018.12.001
关键词
-
类别
资金
- Irvington Institute Fellowship Program of the Cancer Research Institute
- Ovarian Cancer Research Fund Alliance
- Ovarian Cancer Academy Early-Career Investigator Award of the Department of Defense [W81XWH-16-1-0438]
- Stand Up to Cancer Innovative Research Grant [SU2C-AACR-IRG-03-16]
- Pershing Square Sohn Cancer Research Alliance
Protective anti-tumor immune responses are mediated by effector molecules that enable successful elimination of malignant cells. As the site where transmembrane and secreted proteins are generated, the endoplasmic reticulum (ER) of immune cells plays a key role in this process. Recent studies have indicated that adverse conditions within tumors perturb ER homeostasis in infiltrating immune cells, which can impede the development of effective anticancer immunity. Here, we describe how the tumor microenvironment induces ER stress in immune cells, and discuss the detrimental consequences of persistent ER stress responses in intratumoral immune populations. We also explore the concept of targeting ER stress responses to reinvigorate endogenous anti-tumor immunity and enhance the efficacy of various forms of cancer immunotherapy.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据