期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 44, 期 3, 页码 273-292出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2018.10.001
关键词
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资金
- Ministry of Science and Technology of China [2016YFA0500100]
- National Natural Science Foundation of China [91754102, 31771568, 31690102, 31600651]
- 111 Project of the Ministry of Education of China [B16036]
- Natural Science Foundation of Hubei Province [2016CFA012, 2017CFB617]
- National Health and Medical Research Council (NHMRC) of Australia [1141939, 1144726]
- NHMRC
- National Health and Medical Research Council of Australia [1141939, 1144726] Funding Source: NHMRC
Cholesterol is dynamically transported among membrane-bound organelles primarily by nonvesicular mechanisms. Sterol transfer proteins (STPs) bind cholesterol in their hydrophobic pockets and facilitate its transfer across the aqueous cytosol. However, STPs alone may not account for the specific and efficient movement of cholesterol between intracellular membranes. Accumulating evidence has shown that membrane contact sites (MCSs), regions where two distinct organelles are in close apposition to one another, can facilitate STP-mediated cholesterol trafficking in a cell. At some MCSs, cholesterol can move against its concentration by using phosphatidylinositol 4-phosphate (PI4P) metabolism as the driving force. Finally, the emergence of more MCSs and the discovery of a new STP family further highlight the crucial roles of MCSs and STPs in intracellular cholesterol transport.
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