Natural product applications of liquid-phase microextraction

As a simple, rapid, green, and highly-efficient sample-preparation technique, liquid-phase microextraction has been successfully coupled with various instrumental analysis methods and widely applied to determine target analytes (especially trace or ultratrace) from different natural products. In this review, the study is centered on the up-to-date (2017/2018) applications and progresses of various liquid-phase microextractions, mainly including dispersive liquid-liquid microextraction, floating solidification liquid-phase microextraction, hollow fiber liquid-phase microextraction and electromembrane extraction and other novel procedures in the analysis of the endogenous chemical compositions, such as active, nutritional and toxic components from plants as well as disease marker, hormone, neurotransmitters from animals. Finally, future development and applications of liquid-phase microextraction in complex sample analysis are prospected. (C) 2018 Elsevier B.V. All rights reserved.